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Long-term drinking can affect multiple links of the gut-liver axis, such as damaging the intestinal mucosal barrier function, inducing intestinal flora imbalance, and abnormal bile acid metabolism ( Several clinical trials have shown that probiotics such as Lacticaseibacillus rhamnosus LGG improve acute or chronic alcoholic liver injury by regulating intestinal flora and repairing intestinal barrier function ( Rifaximin is a non-systemic antibiotic with broad-spectrum antibacterial activity and has high safety characteristics due to low intestinal absorption (Yang et al., 2024

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As these research directions continue to deepen, GPx4-targeted therapies will bring breakthroughs in the treatment of a variety of diseases, which will not only provide new treatment options for cancer patients, but also is expected to open up new avenues in the fields of neuroprotection and cardiovascular disease prevention, and to promote the development of individualized medicine to a higher level