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Next, 100 nl of compounds were transferred using a JANUS MDT Workstation (Revvity) and a 384-well pin tool (V&P Scientific)

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In turn, Aβ peptides induced enhancer hypomethylation in genes regulating neurogenesis and cell cycle, driving the formation and propagation of tangle pathology, ultimately leading to neuronal death and the cognitive deficits characteristic of AD (Li et al., 2019)