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Pharmacology of HIF-PHIs HIF-PHIs in current clinical development are potent reversible inhibitors of all 3 PHD isoforms, with in vitro half-maximal inhibitory concentrations in the submicromolar to low micromolar range (Table 168, 69, 70, 71, 72, 73, 74, 75, 76)

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La tolérance individuelle varie – certaines peuvent augmenter progressivement jusqu'à 500-750 mcg/jour, mais la prudence est de mise