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Furthermore, in vitro studies have demonstrated that high-glucose conditions dose-dependently suppress PPARα activity in astrocytes, increasing their susceptibility to ferroptosis, and gemfibrozil, a PPARα agonist, inhibits ferroptosis in db/db mice and astrocytes [160]

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Chemical structures of vitamin E isoforms The figure shows the chemical structures of vitamin E isoforms in two panels: Panel A: Natural α-tocopherol, produced by plants, has an RRR -configuration at the 2, 4′, and 8′ of the molecule