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In this case, the mean of the two closest values (MC2) was assigned to MMC2

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Subsequent studies demonstrated that local regulation of the second messenger within the cell results from the combination of different factors, including the cellular localization and activity of specific families of cAMP degrading enzymes, i.e., phosphodiesterases, physical barriers to cAMP diffusion and its buffering by PKA, altogether shaping the spatial distribution and kinetics of cAMP fluctuations, and its access to the intracellular targets (Zaccolo and Pozzan, 2002