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Uptake of B 12 in the gastrointestinal system requires binding of a glycoprotein called intrinsic factor, which is secreted by gastric parietal cells

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We confirmed, although less efficiently reacting with the Ub-PA probe compared to the SUMO1/3-PA probes, SnCE1 shows weak DUB activity cleaving Lys11-, Lys48- and Lys63-linked di-ubiquitin (diUb) chains, with preference for the latter (Fig