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Furthermore, the increased ejaculatory latency induced by SSRIs may result in a number of negative effects on semen quality, including higher DNA fragmentation in sperm, increased prolactin (PRL) levels, decreased testosterone levels, and sexual dysfunction in some men, potentially inhibiting male reproduction (Figure 3) ( 5 Effects of SSRIs on the reproductive system of aquatic organisms SSRIs are a major class of drugs of environmental concern, and fluoxetine, a psychoactive agent, is one of the best-selling prescription antidepressants in the world, which increases the likelihood of aquatic environmental contamination through municipal, industrial, and hospital discharges, potentially inducing sublethal effects in non-target species
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