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In addition to the above differential gene expression, HSC1 and HSC2 expressed different levels of key secreted cytokines ( Ccl2, Ccl21 and Il32 ), chemokines ( Cxcl12 and Cxcl14 ), angiogenins ( Angptl1, Angptl2 and Angptl6 ) and mitogens ( Hgf, Hdgf, Vegfc and Pgf ) (Payen et al., 2021)

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After 40, melatonin production declines measurably , pineal calcification accelerates, and sleep architecture progressively deteriorates