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Anticancer peptides (ACPs) have many unique advantages compared to chemotherapy drugs, such as biocompatibility, efficient therapeutic efficacy, low risk of drug resistance appearing in tumor cells, and limited or no toxicity against mammalian cells ( in vivo , making it possible for them to be put into clinical anti-cancer drug candidates ( 2 The structural classifications and selective recognition to tumor cells of AMPs Generally, the naturally produced AMPs are cationic and amphipathic, with the net charge at neutral pH ranging from + 2 to + 9 (Maroti et al., 2011)