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and colleagues unraveled that CAF showed higher expression of Ephrin B1, B2, and B3 ligands (EFNB1, EFNB2, and EFNB3) compared to NF

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In addition, supplementation of vascular smooth muscle cells (VSMCs) with metformin can enhance the antioxidant capacity of VSMCs, inhibit ferroptosis, and attenuate hyperlipidemia-related vascular calcification through the activation of Nrf2 signaling [101]