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That is, by inhibiting the TGF-β1-induced downregulation of Cx43 protein levels, AS-IV can interfere with PI3K/AKT/mTOR signaling, attenuate the expression of the mesenchymal marker α-SMA and vimentin and further prevent TGF-β1-induced RTEC EMT

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[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Mura S., Nicolas J., Couvreur P