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This is consistent with our results, as cisplatin doesn’t seem to trigger ferroptosis in NB, and with the concept of drug-tolerant persister cells that are induced by cisplatin in NB 82 and exhibit a transition toward a MES-like cell state 12,13

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Ultimately, current guidelines recommend the use of both pharmacologic and nonpharmacological options (including psychotherapy and/or community‐based peer support) in the management of AUDs (Reus et al., 2018)