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The mechanisms underlying cancer drug resistance are complex and multifactorial, including alterations in drug targets, increased drug efflux through transporters such as ATP-binding cassette family, drug inactivation, changes in the cell cycle, and evasion of apoptotic pathways through downregulation of pro-apoptotic proteins like BCL2-associated X [13]

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[DOI] [PubMed] [Google Scholar] [149].Zhang WJ, Frei B