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Obliteration of the sac prevents empyema formation but does not present a barrier to the infection as it spreads outwards to involve not only the thoracic skeleton but also the soft tissues and skin of the chest wall, often with the establishment of the draining sinuses that are a classic, if rare, feature of the disease

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“As macrocyclic agents are taking over the market,” he remarks, “we’re seeing quite a few complaints of gadolinium deposition disease from these agents.” He terms the development puzzling in light of macrocyclics’ presumed lower gadolinium deposition compared to linear