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In an evaluation of protein oxidation detected using a fluorescent probe targeted to sulfenic acid (DCP-Rho1) applied to cells activated with the lipid growth signal lysophosphatidic acid (LPA), our group recently found evidence for enhanced protein oxidation around “redoxosomes” (ROS-generating, signaling endosomes) which were also enriched in internalized LPA receptors [134]

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In the present study, reduced abundance of Actinobacteria in CAG rats reduced their effective metabolites, leading to exacerbation of CAG