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Next, invest in contact-site biology by creating tools and reference atlases that resolve microdomain redox at organelle interfaces (MAMs, peroxisome–mitochondria, mitochondria–lysosome) and plasma-membrane nanodomains, because that is where signalling turns into damage (Xia et al

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This is important to note given that high dose antioxidants may paradoxically increase reactive oxygen species and inflammation levels in the body