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Thus, the impaired expression of lipid-regulating genes appears to have a significant impact on the etiology of OA by contributing to lipid buildup and its negative effects on cartilage health ( The synovium consists of macrophages, fibroblasts, and endothelial cells ( IL-1 and TNF-α , which generate MMPs and inhibit the production of collagen and proteoglycan, leading to low-grade synovitis ( Figure 1 )

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Methods STING expression was detected in human renal biopsy tissues and serum samples from patients with DKD