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This is consistent with the known role of fatty acyl-CoAs in allosteric inhibition of the acetyl-CoA consuming enzyme ACC 25,26 , which may divert acetyl-CoA towards histone acetylation, as previously reported 27–29

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2.3 Abnormal antioxidant defense The cell possesses antioxidant defense systems that regulate lipid reactive oxygen species (ROS) and lipid peroxides to counteract ferroptosis