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Nutrients, Growth Factors, and mTORC1 The signal transduction cascade from hormones/growth factors that activates the mTOR kinase starts with the activation of a receptor tyrosine kinase at the plasma membrane that switches on the PI3K–Akt axis, which results in the inhibition of the tuberous sclerosis complex (TSC)

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Peptides were analysed using a repeating cycle consisting of a full precursor ion scan (AGC standard