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Generally, NNMT activity or expression is significantly elevated in cancers, such as brain [68], lung [69], liver [70], kidney [71, 72], bladder [73], stomach [74, 75], pancreas [76], colon [77], and oral [78, 79] cancer but cancer cells usually have a significantly higher anaerobic metabolism rate than normal cells
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The following mechanisms explain why it occupies such a prominent place in research on energy metabolism and aging: NAD+ is used in research in the milligram range, not the microgram range that applies to many classic peptides