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In contrast, ADx + CORT mice did not display a similar diurnal rhythm (Fig

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Similar to what is described above for “early onset PCO”, these cells are expected to be subject to the same growth factor gradients within the eye as the intact lens, so LECs closer to the anterior capsule would be more likely to retain their LEC phenotype, while those more exposed to the high concentrations of FGF ligands found in the posterior chamber would be induced to form fiber-like cells (192, 285, 288)