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These studies demonstrate that MIA not only causes inflammation but also oxidative stress via mitochondrial dysfunction, which damages the mother, placenta, and fetus, resulting in the risk of ASD and neurodevelopmental abnormalities in the offspring
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One of these genes, the target protection PMQR gene qnr ( qnrA, qnrB, qnrC, qnrD , and qnrS ), generates proteins that prevent damage to the quinolone targets gyrase and topo IV (Strahilevitz et al., 2009