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For example, the use of manganese dioxide (MnO 2 ) and gold–platinum (Au-Pt) NPs helps to modify the tumor immunosuppressor microenvironment because they act as generators of radioactive nano-oxygen (nanobubbles composed of gas such as oxygen), improving the infiltration of cytotoxic T cells, affecting the cancer cells’ metabolism and reducing their proliferation by downregulating the expression of hypoxia-inducible factor 1α (HIF-1α) and C-MYC [183], and consequently, tumor progression [184,185]