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(2023) loaded the hydrophobic core of amphiphilic polycarbonate cationic nanoparticles with the nerve growth factor receptor antagonist TrkA-IN-1 and incorporated the drug-loaded nanoparticles into a decellularized annulus fibrosus matrix (DAF) hydrogel, which could inhibit the formation of a chronic inflammatory microenvironment by pro-inflammatory factors and nerve growth factor-induced nerve ingrowth into the annulus fibrosus

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For instance, upregulating GPX4 in ferroptosis-sensitive chondrocytes, restoring antioxidant defenses in inflammatory synovial macrophages, or rebalancing iron export in subchondral osteoblasts may prevent tissue-specific degeneration