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Other secondary end points included overall response and safety.[37] At a median follow-up of 12 months, the median PFS was not reached in the selpercatinib group and was 16.8 months in the control group (95% CI, 12.2–25.1) (HR disease progression or death , 0.28

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The fact that the correlation of SAM levels and lifespan is not bidirectional implies a threshold in SAM levels that modulate organismal lifespan