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Mutations in the CAT gene were found in 10% of the melanoma patients, mostly leading to increased mRNA expression, but these mutations had no significant impact on survival [34]
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Abbreviations γ- GGT γ-glutamyltransferase ADP adenosine diphosphate AIF apoptosis inducing factor Apaf-1 apoptotic protease activation factor-1 APE apurinic/apyrimidinic endonuclease ASK-1, -2 apoptosis signal-regulating kinase 1, -2 ATP adenosine triphosphate Bax pro-apoptotic protein Bax Bcl-2 anti-apoptotic protein BER base excision repair Bid BH3-only pro-apoptotic protein Bid BIR Baculovirus IAP repeat BSO buthionine sulphoximine CARD caspase activation and recruiting domain caspase-8,-9,-3 active form of caspase-8,-9,-3 CJ cristae junction CL cardiolipin CL-OOH peroxidized cardiolipin cypD cyclophylin D Cys cysteine cyt c cytochrome c DCVC S-(1,2-dichlorevinyl)-L-cysteine DED death effector domain DIC dicarboxylate carrier DISC death-inducing signalling complex DP dipeptidase ER endoplasmic reticulum FADD Fas-associated death domain FasL Fas ligand G6PD glucose-6-phosphate dehydrogenase GAPDH glyceraldehyde-3-phospate dehydrogenase GCL glutamate-cysteine ligase Glu glutamic acid Gly glycine GPx GSH peroxidase GR GSH reductase GS glutathione synthase GSH glutathione GSSG glutathione disulphide H2O2 hydrogen peroxide HDM2 human double minute 2 protein IAA iodoacetic acid JNK c-Jun N-terminal kinase MPT mitochondrial permeability transition mtDNA mitochondrial DNA mtGSH/GSSG mitochondrial GSH/GSSG NAC N-acetylcysteine NER nucleotide excision repair NO • nitric oxide OGC oxoglutarate carrier OGG1 8-oxodG glycosylase OPA1 optic atrophya 1 protein PTP permeability transition pore ROS reactive oxygen species RNO reactive nitrogen species Smac/Diablo second mitochondria-derived activator of caspases/direct IAP binding protein with low pI t BH tert -butyl hydroperoxide tBid truncated form of Bid TCDD 2,3,7,8-tetrachloredibenzo-p-dioxin TRAF2/6 TNFα receptor-associated factor 2/6 Trx1 thioredoxin 1, reduced form Trx2 thioredoxin 2, reduced form TRX-S-S thioredoxin, oxidized form UPR unfolding protein response VDAC voltage-dependent anion channel Footnotes This article may be used for research, teaching and private study purposes
