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31,32 Lung cancer, which is responsible for an estimated 2.2 million new cases and 1.79 million deaths annually, arises from both genetic predispositions and environmental risk factors

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Glutathione reductase (GR) reduces glutathione disulfide (GSSG) and drives the GSH-dependent systems [7,8], whereas Trx reductases (TrxR) are pivotal in the Trx-dependent system (Figure 1) [9]