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Additionally, due to the negative charge of cartilage, positively charged MNPs have a higher propensity to enter cartilage, and the retention of MNPs in cartilage tissue facilitates the gradual release of metal ions

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Future research must prioritize the development of specific in vivo biomarkers, the advancement of pathophysiology-targeted imaging tools, and the implementation of well-designed clinical trials targeting key nodes of the ferroptosis pathway