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146 Vitamin D is important as an immune system regulator 145 and, given that low serum 25-OH vitamin D levels have been associated with many chronic diseases (eg, autoimmune disease, cardiovascular disease, and infections), 146 vitamin D supplementation may be an important therapeutic strategy for COPD that is worthy of further investigation

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As opposed to bronchial epithelium, the alveolar epithelium comprises an extremely thin monolayer of type I ECs, which cover over 95% of the inner alveolar surface