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Pharmaceutical companies receiving FDA approval for a new drug application (NDA) are required to submit to the FDA a list of patents covering the drug product under Section 505(b)(1) of the Federal Food, Drug, and Cosmetic Act (FD&C Act), codified at 21 U.S.C

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Generally, the efficiency and sensitivity of drugs to affect the enzymatic activity, energy consumption, and cell proliferation can be analyzed by various types of in vitro drug sensitivity tests (280)