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In agreement with previous studies, the experimental findings of this study demonstrate that obesity significantly increases the expression levels of TLR4 and MyD88 proteins as well as the phosphorylation levels of IκBα and NF-κB p65, along with pro-inflammatory cytokine levels in the intestinal tissues of DIO mice
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Long-term oxidative stress and chronic low-grade inflammation may be involved in endothelial dysfunction, abnormal vascular reactivity, and the progression of atherosclerosis, and are considered potential bridging mechanisms for the increased risk of coronary heart disease, heart failure, and other cardiovascular events in COPD patients (148, 149)
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