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The drug is generally well tolerated and has an exceptionally wide veterinary safety margin (in horses, tolerance extends to roughly 100 times the therapeutic dose), but a small number of human case reports document drug-induced liver injury (DILI) at high, self-administered doses

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Furthermore, previous studies have shown that, unlike other skin-related cells such as fibroblasts and endothelial cells, the proliferation and migration ability of hair follicle cells is directly related to the cell growth cycle