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For instance, when dietary bovine gangliosides were provided to weanling rats, multiple changes in the intestinal epithelium were observed, including an increase in the content of ether phospholipids (a group of phospholipids with an alkyl or alkenyl bond at the sn -1 position) (39), greater incorporation of LC-PUFAs such as DHA and ARA ( ex vivo study, pre-exposure of infant bowel tissue to gangliosides reduced bowel necrosis and pro-inflammatory signals in response to LPS, implying an in vivo functional re-structuring of enterocytes (155)
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Studies such as this one published in PMC highlight the role of malabsorption from mucocutaneous disorders like epidermolysis bullosa can lead to deficiencies that cannot be addressed adequately with oral supplements
