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Post-translational modifications such as oxidation, methylation, acetylation, methionine loss, and cysteine oxidation were observed in NRF2-induced RS hearts, affecting both transcription and translation due to protein aggregation [119]

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Thus, 4HB synthesis starts with the deamination of tyrosine to 4-hydroxyphenylpyruvate by Aro8 and Aro9 and finishes with the oxidation of 4-hydroxybenzaldehyde to 4HB by Hfd1

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