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Abstract The cellular defense system against exogenous substances makes therapeutics inefficient as intracellular glutathione (GSH) exhibits an astounding antioxidant activity in scavenging reactive oxygen species (ROS) or reactive nitrogen species (RNS) or other free radicals produced by the therapeutics

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In summary, the case for using calmangafodipir as an antidote against APAP toxicity in patients remains unconvincing