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Repletion of vitamin B12 may improve response in patients resistant to antidepressants (10) , and in older adults with major depression, long-term supplementation with a combination of B12, B6, and folic acid enhanced antidepressant treatment efficacy (40)

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Mecobalamin is often used to address symptoms related to nerve disorders, including tingling, numbness, and pain, and is sometimes prescribed to improve nerve regeneration in patients with diabetic neuropathy