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Neurobiological and Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) and DHEA Sulfate (DHEAS) - PMC

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Lot #:Lot #: N9GHKCU50/0328

When rat cerebral cortical cultures were subjected to anoxia for two hours in an anaerobic chamber and pretreated with DHEA (10 −8 and 10 −6 M) or DHEAS (10 −6 M), there was increased neuronal survival [190].This increase in neuronal survival was not due to metabolism of DHEA(S) into estradiol, since concentrations of 17β-estradiol were not detectable in culture media [190]