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The Metabolic Underpinnings of Ferroptosis: Cell Metabolism

In summary, CASE promotes cancer inhibitory signal output by activating the MAPK-dependent linker dephosphorylation of Smad2/3, further targeting the downregulation of PAI-1 expression, thereby inhibiting MAPK to regulate cancer-inducing signals related to TGF-β/Smad

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10.1016/j.phymed.2024.156166