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Introduction Glutathione S -transferases (GSTs) are phase II detoxifying enzymes that are responsible for detoxifying xenobiotics and endogenous metabolites of oxidative stress ( via blocking the mitogen-activated protein kinase (MAPK) signaling pathway ( Apc Min/+ mouse model, in which the deletion of GSTP1 results in increased colon cancer incidence and tumor multiplicity ( The human alpha class GST consists of 5 isozymes that are responsible for detoxifying a broad range of xenobiotics, namely, carcinogens, mutagens, chemotherapeutic drugs, steroids, and byproducts of oxidative stress ( Adjuvant chemotherapy has significant survival benefits for patients with late-stage CRC
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Notably, in APC-mutant CRC, APC deficiency upregulates TCF4/β-catenin-dependent TDO2 transcription, activating the Kyn-AhR axis to boost glycolysis for anabolic growth and CXCL5-mediated macrophage recruitment (200)
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