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While you could technically take a supplement containing NAD+ as the primary ingredient, research suggests that its bioavailability isn’t nearly as good as two of its precursors: nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN).46 Besides NAD+, NR is also a precursor to NMN.47 And since NMN is “closer” to becoming NAD+ than NR is, some people feel that it’s the better option, but either one should be effective.48 If you’re interested in these supplements, it could be worth trying one of each type (NR or NMN) to see which works better for you

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According to studies, hypertension may cause the gut-blood barrier to become more permeable, allowing more TMA to enter the bloodstream and raising the quantity of TMAO [55]