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Since the valinomycin synthetase Vlm shows the same genetic architecture as Ces, it is tempting to speculate that the novel mechanism of non-ribosomal peptide assembly proposed in this study is not a specificity of the cereulide synthetase but a more common logic for biosynthesis of ester bond containing NRPS products, thereby contributing to biodiversity of natural depsipeptide products

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Regeneron estimates that about 220 patients in the US are candidates for Pasatru (garetosmab), which won FDA approval for fibrodysplasia ossificans progressiva