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PAR2-G37I [ B6(Cg)-F2rl1 tm2.1Wmrf /Tarc ] and PAR2-R38E [ B6(Cg)-F2rl1 tm1.1Wmrf /Tarc ] mutant mice were generated by homologous recombination of sequence-confirmed mutated F2rl1 exon 2 with flanking introns 1 and 2 into pBS-FRT-Neo-FRT in C2 C57BL/6N embryonic stem cells at the Scripps Transgenic Core Facility (30)

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CD44 acts as a signaling platform controlling tumor progression and metastasis