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The interaction between the E3 ligase Nedd4 and the β 2 -AR is mediated via β -Arr 2, which serves to link E3 ligase Nedd4 to the activated receptor indicating that ubiquitination of the β 2 -AR is a prerequisite for its degradation, whereas ubiquitination of β -Arr 2 is essential for receptor internalization (Shenoy et al., 2001)

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With the correct research and regulatory approval though, isn’t this a class of drug which may offer “patients suffering from injuries another avenue that aids in joint preservation, tissue regeneration, and improved pain relief” with no performance enhancing effects