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The Spine Journal

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However, administration of calcitriol or activation of renal calcium reabsorption by a retinoid derivate restored plasma IGF-1 levels.110 Importantly, chondrocytes isolated from rats with renal insufficiency also show decreased response to the anabolic effects of IGF-1 compared to chondrocytes from rats with normal renal function,111 suggesting that intracellular alterations as causing factors for IGF-1 resistance