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NICE CG191 recommends severity assessment using CRB-65 to guide site-of-care and antibiotic choice) Doxycycline or clarithromycin (alternatives) For inflammatory bowel disease , where sulfasalazine (contraindicated in sulphonamide allergy per SmPC) might otherwise be used, alternatives include: Mesalazine (5-aminosalicylic acid without the sulphonamide component) Balsalazide or olsalazine (other 5-ASA derivatives) (NICE NG129 for Crohn's disease

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