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In this context, FOXO3 has either a positive or a negative effect depending on the function status, cell type, and severity of the stress stimulus: while constitutive activation has proapoptotic effects leading to neuronal loss, inhibition of FOXO-mediated transcription by a dominant-negative competitor causes oxidative damage and is detrimental at high vector dose in neurons

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doi: 10.1021/acs.jafc.2c06125