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The tetramer form is exposed to two high-affinity zinc ion binding sites (the crucial sites for functions) at the interface of the S100A8/S100A9 (calprotectin) complex (105, 106)

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Clinical Trials In recent decades, clinical trials on hemorrhoids have largely focused on compound preparations and natural extracts, yet there is a conspicuous lack of clinical trials concerning the treatment of hemorrhoids with bioactive components from natural products