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How alcohol contributes to vitamin D deficiency Impairs hepatic conversion to active metabolites (55) Disrupts calcium absorption and bone remodeling (56) Common symptoms and clinical consequences of vitamin D deficiency Bone pain or increased fracture risk Muscle weakness Frequent infections Worsening inflammatory or autoimmune conditions Clinically, vitamin D deficiency often goes unnoticed until bone density declines or immune issues become recurrent

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Like GPX4, phospholipase A2 (PLA 2 ) family members have been implicated in modulating ferroptosis sensitivity