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LOXs, a group of iron-containing enzymes, are responsible for catalyzing the PUFAs (with a 1,4- cis, cis pentadiene system) oxidation through stereo-specific peroxidation to produce corresponding fatty acid hydroperoxides (Kuhn et al., 2018)

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Most labs running blinded comparative studies default to subcutaneous for exactly this reason: the variability is lower, the dose-response curve is steeper, and the results replicate more consistently across subjects