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Ten of the top 15 SNPs with the lowest p values among the 1.3 million SNPs analyzed were located in the same region of chromosome 3 (see Table 1)

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Phosphorylated TDP-43 pathology was found to drive the microglial transition from a phagocytically active state, marked by early-stage neuroprotective phagocytic activity via elevated CD68 expression, to a dysfunctional state characterized by late-phase L-ferritin accumulation, thus offering novel insights into ALS pathogenesis (59)